The Diabetes Remission Clinical Trial (DiRECT), funded by Diabetes UK has released it's latest findings 2 years into the trial. The randomised controlled study is led by Professor Mike Lean and compares the effect of a low calorie meal replacement diet and weight management support with current best-practice guidelines for weight loss delivered in GP surgeries across Scotland and Tyneside.
Individuals aged 20-65 years with type 2 diabetes and who were overweight/obese (BMI 27-45) were randomised into an intervention or the control group. The intervention group followed an 850kcal meal replacement programme for 12 weeks before being re-introduced to food followed by structured support for weight-loss maintenance.
149 participants were recruited into each group. At 2 years, 11% of participants in the intervention group achieved a weight loss of at least 15kg compared to the control group at 2%. Weight loss of at least 10kg was maintained by 24% of participants in the intervention group compared to 6% in the control group. Significantly more participants from the intervention group achieved and sustained remission from diabetes compared to the control group: 36% vs 3% respectively (p<0·0001).
Merging the results of both groups, 64% of individuals who managed to maintain at least 10 kg weight loss at 2 years remained in remission from diabetes.
Diabetes UK - News: Weight loss can put Type 2 diabetes into remission for at least 2 years - latest findings from DiRECT [Online]. 2019 Published 6th March 2019. https://www.diabetes.org.uk/about_us/news/weight-loss-type-2-diabetes-remission-direct-latest
Lean MEJ, Leslie WS, Barnes AC et al. Durability of a primary care-led weight-management intervention for remission of type 2 diabetes: 2-year results of the DiRECT open-label, cluster-randomised trial. Lancet Diabetes Endocrinol 2019 Mar 5. Epub ahead of print